Working with Us

Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .

Bristol-Myers Squibb's headquarters located in Princeton, NJ is the heart of a vibrant ecosystem of world-class science and innovation. Our research in Princeton focuses on identifying novel targetable pathways for tumors resistant to current therapies, as well as establishing and deploying innovative discovery and translational medicine platforms to address unmet medical needs in cardiovascular disease, immunoscience, immunology, neuroscience and fibrosis. We also foster external collaborations with biopharma, biotech, and academic partners to help patients prevail over serious diseases.

This is an exciting opportunity to advance our precision medicine efforts by developing tissue-based assays to support patient selection strategies. Applicants chosen for this position will directly interact with diverse clinical and scientific colleagues to advance cutting-edge clinical trials programs. Projects include development of assays using immunohistochemistry, multiplex staining/imaging, in situ nucleic acid hybridization, and digital pathology. The scientist will be directly responsible for the design, development, execution, and analysis of translational tissue-based biomarker assays to interrogate target prevalence, target engagement, mechanisms of action, pharmacokinetics, pharmacodynamics, --and prediction of treatment response. The position entails working on projects independently and in multi-disciplinary teams consisting of pathologists, lab scientists, data scientists and clinical biomarker scientists. The IHC scientist will develop tissue-based assays for internal or external use with accountability for assays transferred to partner labs and contract research organizations (CROs). The scientist will also be responsible for working with digital pathology colleagues to build and assess image analysis algorithms and workflows.

The ideal candidate will have strong technical experience in IHC assay development using several platforms and techniques and a working knowledge of histology/morphology/pathology interpretation relevant to assay development. The scientist must show strong communication and organizational skills, the ability to work collaboratively with other team members, adaptability to regulated work environments and the flexibility to accommodate changing business needs. The applicant will have both wet-lab and management responsibilities.

CORE JOB FUNCTION(S):

• The scientist will coordinate and perform all aspects of assay development spanning project intake, planning, development, and execution of assays including (but not limited to) chromogenic immunohistochemistry (IHC), in-situ nucleic acid hybridization, multiplexed immunofluorescence (mIF) and digital pathology

• Development of assay workflow strategies (feasibility, verification, and validation), with appropriate knowledge and use of controls and test tissues

• Responsible for planning, coordination, and execution of assay transfer to vendor sites with communication/problem solving with the vendor

• Maintain technical proficiency across several IHC, mIF, histology/tissue processing and digital scanner technologies

• Provide concise yet thorough project overviews and timelines to leadership and stakeholders

• Contribute to design control processes and CAP/CLIA lab work, documentation, and planning (when needed)

• Coordinate, execute and document clinical trial sample and commercial sample assay development and deployment within BMS labs

• Capable of working on multiple development projects simultaneously with appropriate project prioritization while also participating in lab management and other lab initiatives

• Perform preliminary scoring of stained slides with the engagement of pathologist oversight and review

• Digital image analysis for assay quality assessment and analysis

• Maintain workplace and lab compliant processes and documentation

• Mentoring and coaching less experienced scientists

• Familiar/keeps current with literature

• Excellent communication and interpersonal skills and can effectively communicate via email, meetings, and reports

• Promotes responsible fiscal practices throughout the lab

• Participates in the development of relevant documentation (e.g., patent applications, publications, SOPs, regulatory submissions, protocols, etc.)

• Participates in continuous improvement or development of new/improved work practices

• Suggests approaches to new ways of working and to improve efficiency

• Moves forward independently to the next logical step of an experiment

• Troubleshoots routine technical problems

• May participate in complex programs/projects within the division

• Capable of meeting deadlines on an independent book of work

• Suggests options to solve complex problems leveraging technical and operational expertise

• Works under limited supervision; reviews work regularly with supervisor/pathologist

• Decisions impact work group/project team

• Proactively promotes and engages in the exchange of ideas, information, and feedback within own group

• Initiates internal subgroups with peers to accomplish goals

• May act as point of contact for a program within own group

• Develops and maintains strong working relationships with colleagues

• Makes presentations in small group meetings with multidisciplinary stakeholders

• This is a lab-based position requiring on-site work >80% of the time (averaged across 2 weeks)

Basic Qualifications:

• Bachelor's Degree with 5+ years of academic and / or industry experience OR master's degree with 3+ years of academic and / or industry experience OR Ph.D. or equivalent advanced degree in the Life Sciences

Preferred Qualifications:

• Research experience in the field of cancer biology and immunology

• Experienced in the design and development of IHC and mIF assays using various technology platforms including but not limited to the Leica Bond RX and Ventana Benchmark Ultra

• Experience using a variety of slide scanner technologies including, but not limited to Zeiss Axioscanner, Leica GT450, Leica AT2 and Akoya Polaris

• Experience managing lab practices including, but not limited to, ordering, inventory, documentation, budgeting, and electronic notebook

• Experience performing basic laboratory work including maintenance of lab equipment, automated IHC equipment and histology equipment

• Ability to conduct experimental work independently, with accurate, detailed record-keeping

• Familiarity with assay qualification/validation guidelines and guidance (FDA, CAP, CLIA, NYSDOH, global regulatory requirements for assay development).

• Basic understanding of IVD quality system standards (21 CFR part 820, ISO13485)

• Knowledge of clinical sample handling, analysis and regulatory and quality frameworks and guidance in the lab and at vendors (such as GCP, CLIA, CAP, and NYDOH)

• Ability to efficiently manage and prioritize multiple projects, coordinating in-house research with collaborative work.

• Ability to summarize and interpret scientific data in a clear, concise, and accurate manner

• Excellent oral and written communication skills

• Ability to communicate well with peers and supervisors

• Exceptional organizational skills and meticulous attention to detail in managing in-lab tasks, personnel, and experimental protocols

• Strong problem-solving skills and understanding of relevant scientific principles

• Mindset focused on continuous improvement, actively seeking opportunities to enhance lab efficiency and safety

If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers

With a single vision as inspiring as Transforming patients' lives through science™ , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ eeo -accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Company: Bristol-Myers Squibb

Req Number: R1581201

Updated: 2024-05-20 02:50:21.579 UTC

Location: Princeton-NJ

Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.